In January 2004, Major League Baseball announced a new drug policy which originally included random, offseason testing and 10-day suspensions for first-time offenders, 30-days for second-time offenders, 60-days for third-time offenders, and one year for fourth-time offenders, all without pay, in an effort to curtail performance-enhancing drug use (PED) in professional baseball. This policy strengthened baseball's pre-existing ban on controlled substances , including steroids, which has been in effect since 1991.  The policy was to be reviewed in 2008, but under pressure from the . Congress , on November 15, 2005, players and owners agreed to tougher penalties; a 50-game suspension for a first offense, a 100-game suspension for a second, and a lifetime ban for a third.
I don’t know about the legality of all the stuff he used, but according to Jane Leavy a number of his treatments are so dangerous they are off the market. She describes one, Butazolidin, as “an anti-inflammatory drug prescribed for broken down thoroughbreds, so poisonous to living things that it was taken off the market in the mid-1970s. It had only one major side effect. It killed a few people”. She describes another, Capsolin, as having an active ingredient, “capsaicin, (that) works by depleting substance P, the brain’s pain messenger. It is the medical equivalent of hitting your head against a brick wall.” She goes on to describe its “atomic balm” effect, noting an instance when Lou Johnson wore an insufficiently washed Koufax sweatshirt and began to sweat, then had his skin blister and finally threw up. It too is off the market.