Disturbingly, as written in BusinessWeek early in 2008, "Some researchers have even suggested -- half-jokingly -- that the medications should be put in the water supply." 12 Count yourself lucky that you probably do NOT need to take cholesterol-lowering medications, because these are some nasty little pills. Statin drugs work by inhibiting an enzyme in your liver that's needed to manufacture cholesterol. What is so concerning about this is that when you go tinkering around with the delicate workings of the human body, you risk throwing everything off kilter.
As indicated in the Figure above showing the pathway of cholesterol biosynthesis a molecule of geranylpyrophosphate (GPP) and a molecule of isopentenylpyrophosphate (IPP) are condensed into farnesylpyrophosphate (FPP) through the action of the farnesyl diphosphate synthase enzyme which is encoded by the FDPS gene. Through the action of the ER-localized enzyme, dehydrodolichyl diphosphate synthase (encoded by the DHDDS gene), farnesylpyrophosphate is elongated via the sequential head-to-tail addition of multiple isopentenylpyrophosphate groups in a reaction referred to as cis -prenylation. The number of IPP substrates added ultimately determines the overall number of isoprene units in dolichol which in humans ranges from 17 to 21. The DHDDS gene is located on chromosome and is composed of 10 exons that generate five alternatively spliced mRNAs each of which encode a distince protein isoform. The product(s) of the DHDDS reaction is referred to as a polyprenolpyrophosphate. The pyrophosphate is removed by an as yet uncharacterized enzyme activity that may be either a polyprenol pyrophosphate phosphatase or a polyprenol phosphatase resulting in the formation of a polyprenol.
I have been taking statins for some years now, following an initial fasting result of – I am now at , and was put on Crestor 40mg plus Exetrol 10 mg by the lipid clinic at Edinburgh Hospital – I was sent there to find out if there was a genetic link – my male cousin had a level of 14 and heart attack at 50 – but in my case it isn’t genetic. I have recently started to see a nutritionist who suggested reading your blog and Matthew Kendrick’s The Cholestrol Con’, and I am wondering if it,is ok for me to come off the statins or at would I still be at risk. I have recently been told by my new GP practice that my blood sugar levels are raised and that puts me in the pre- diabetic range, I have raised liver function results and low thyroid. Liver function has been slightly raised for sometime and for years I thought I might have low thyroid but tests with my previous GP always indicated not – although a private slimming doctor did at some stage put me on thyroxin because he judged the tests to indicate low level in the blood. I have always felt I was pretty healthy until now! Your thoughts please..