Corticosteroids function of the hormone

Direct intravenous injection:
Use only methylprednisolone sodium succinate.
Reconstitute with provided diluent or add 2 ml of bacteriostatic water (with benzyl alcohol) for injection.
May be administered undiluted.
Administer directly into a vein over 3—15 minutes. Doses >= 2 mg/kg or 250 mg should be given by intermittent infusion (see below), unless the potential benefits of direct IV injection outweigh the potential risks (., life-threatening shock).
 
Intermittent intravenous infusion:
Use only methylprednisolone sodium succinate.
Dilute in D5W, % Sodium Chloride (NS), or D5NS injection. Haze may form upon dilution.
Infuse over 15—60 minutes. Large doses (., >= 500 mg) should be administered over at least 30—60 minutes.

ABSTRACT. The influence of glucocorticosteroids on plasma volume, thyroid hormones and thyroid hormone-binding proteins was studied in 17 patients. Plasma volume was not affected either by . betamethasone (6 mg daily) or by oral prednisolone (45–180 mg daily) given for 5 days. The serum T 3 concentration decreased while rT 3 increased independently of the route of administration of corticosteroids. Serum T 4 concentration decreased after . but not after oral administration of corticosteroids. Oral steroids as compared to . increased the 125 I-triiodothyronine uptake test value. The serum TBG concentration decreased independently of the route of administration, while the serum TBPA concentration increased after oral corticosteroids but was unchanged after . treatment. The serum TSH concentration was slightly reduced. About half of the patients were given both corticosteroids and nutrition . and the other half were given all treatment by mouth. The part played by the route of administration of corticosteroids and calories, respectively, cannot be evaluated at present but these factors seem to be of importance.

Corticosteroids function of the hormone

corticosteroids function of the hormone

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