Dhea steroid pathway

Protection against one particular research toxin (7,12-DMBA) has been noted with acute usage of 9mmol/kg calcium-D-glucarate ( 3 hours prior to and another dose 30 minutes prior to DMBA injections) which reduced tumor occurrence from 100% to 30% [7] and studies with more chronic loading have noted benefit with dietary supplementation of 75mmol/kg (of the diet, /kg bodyweight and 213mg/kg human equivalent). [1] [7] This protective effect extends beyond breast cancer and is able to attenuate skin cancer with either calcium-D-glucarate itself [22] or the main bioactive metabolite [23] (skin cancer is known to be able to be induced by DMBA [24] ) and may also extend to DMBA induced oral cancers. [25]

ONC1-0013B inhibits AR activity in vitro. A. ONC1-0013B structure. B. LnCAP cells cultured (10% CSS) for 3 days, then treated with tested compounds in presence of 1nM DHT for 1 day. PSA expression plotted as percentage of vehicle control (DMSO; n=2, mean±SEM). Ki values: ± (ONC1-13B), ± (MDV3100), (ARN-509). Mean±SEM from 5 replicate experiments (except ARN-509). C. LnCAP cells cultured (10% CSS) for 3 days, then treated with tested compounds in presence of 1nM DHT for 5 days. Viable cells plotted as percentage of vehicle control (DMSO; n=2, mean±SEM). IC50 values: 30nM (ONC1-13B), 148nM (MDV3100), 240nM (ARN-509). D. Competitive-binding assay vs AR ligand Fluormone™ (PolarScreen™ Androgen Receptor Competitor Assay). IC50 values: 19nM (DHT), (ONC1-13B), (MDV3100).

ARN-509 (< 10 μM) inhibits androgen-mediated induction or repression of mRNA expression levels for 13 endogenous genes including PSA and TMPRSS2 in the LNCaP/AR prostate cancer cell line. ARN-509 (< 10 μM) inhibits the proliferative effect of R1881 (30 pM) in the LNCaP/AR prostate cancer cell line. ARN-509 (10 μM) impairs AR nuclear localization and thus reduces the concentration of AR available to bind androgen response elements (ARE) in LNCaP cells expressing AR-EYFP. ARN-509 (10 μM) is able to effectively compete with R1881 (1 nM) and prevent AR from binding to promoter regions. ARN-509 inhibits R1881-induced VP16-AR–mediated transcription with IC50 of μM in Hep-G2 cells expressing a VP16-AR fusion protein and an ARE-driven luciferase reporter. [1]

The labels claim DHEA will help us lose weight , rev up our libido, lift depression and give us back the strength, immunity, and stamina we had when we were 20 — the age at which our bodies naturally produced the most DHEA. While on the surface this is appealing (who wouldn’t want to feel 20 again?), it’s obviously not what nature intended. We also don’t know enough about DHEA to be conducting such a large, unregulated public experiment. DHEA is a potent steroid — that’s why it made headlines and why it should be approached with due diligence.

Dhea steroid pathway

dhea steroid pathway

The labels claim DHEA will help us lose weight , rev up our libido, lift depression and give us back the strength, immunity, and stamina we had when we were 20 — the age at which our bodies naturally produced the most DHEA. While on the surface this is appealing (who wouldn’t want to feel 20 again?), it’s obviously not what nature intended. We also don’t know enough about DHEA to be conducting such a large, unregulated public experiment. DHEA is a potent steroid — that’s why it made headlines and why it should be approached with due diligence.

Media:

dhea steroid pathwaydhea steroid pathwaydhea steroid pathwaydhea steroid pathwaydhea steroid pathway

http://buy-steroids.org