With a few exceptions as noted below, one should avoid using all medications in pregnant and lactating (nursing) dogs. There may be instances in which a medication not recommended for use during pregnancy may need to be used to save the life of the bitch, even though it may potentially harm the fetuses.
NOTE: According to the Merck Veterinary Manual , this is only a partial listing of drugs that should be avoided in pregnant or nursing dogs. A listing of all such drugs is beyond the scope of this article. If you have concerns regarding a specific drug, make sure you do an internet search for that particular drug or purchase a copy of the Merck Vet Manual to have on-hand.
Two similarly-designed, randomized, double-blind, placebo-controlled studies were conducted in a total of 970 adult patients with active, mild to moderate ulcerative colitis (UC) which was defined as an Ulcerative Colitis Disease Activity Index (UCDAI of ≥ 4 and ≤ 10). Eight-hundred ninety-nine of these patients had histology consistent with active UC; this was considered the primary analysis population. UCDAI is a four-component scale (total score of 0 to 12) that encompasses the clinical assessments of stool frequency, rectal bleeding, mucosal appearance and physician's rating of disease activity (score of 0 to 3 for each of the components).