Corticosteroids have been used to control MS relapses for decades. Data on the effectiveness of these medications in MS comes from four randomized, placebo-controlled studies of intravenous and oral methylprednisolone. Altogether, these studies included 74 people with MS who received corticosteroid treatment and 66 who received placebo. Corticosteroid treatment with methylprednisolone resulted in greater speed of recovery from exacerbation compared with placebo. However, treatment did not decrease the risk of future relapses or decrease the progression of disability.