Although there was a non-significant reduction in the number of hip fractures (9 on Tamoxifen, 20 on placebo) in the Tamoxifen group, the number of wrist fractures was similar in the two treatment groups (69 on Tamoxifen, 74 on placebo). A subgroup analysis of the P-1 trial, suggests a difference in effect in bone mineral density (BMD) related to menopausal status in patients receiving Tamoxifen. In postmenopausal women there was no evidence of bone loss of the lumbar spine and hip. Conversely, Tamoxifen citrate was associated with significant bone loss of the lumbar spine and hip in premenopausal women.
I believe another very important preventative is to never, ever again purchase water in plastic bottles. Once that water is heated inside the soft (squishy) plastic, the plastic begins to leach out xenoestrogens. This also occurs when the bottles of water are frozen, especially for “taking along” on hot summer days. While most people who purchase bottled water will not leave the case in a hot car, we don’t know how the bottles were handled BEFORE purchase. During the summer, we see the bottled water companies transporting their wares to stores in delivery trucks–in the hot sun. How hot does it become inside those delivery trucks…and what were the temperatures when the bottles were stored before delivery? Are they stored in climate-controlled warehouses, or do the temperatures inside rise well above ambient temperatures in the summer or fall near freezing in the winter? Food for thought. As a physician, I have been advising patients for 20 years to Never, Ever purchase or drink water from soft plastic bottles of bottled water.