Patients in the MTX monotherapy group were twice as likely to discontinue from the study due to adverse events compared to patients in the placebo group, at 12 to 52 weeks (16% versus 8%; RR , 95% CI to ; NNT 13, 95% CI 6 to 44). Compared to placebo, nine more people out of 100 who took MTX withdrew from the studies because of side effects (ATB 9%, 95% CI 3% to 14%). Total adverse event rates at 12 weeks were higher in the MTX monotherapy group compared to the placebo group (45% versus 15%; RR , 95% CI to ; NNT 4, 95% CI 2 to 17). Thirty more people out of 100 who took MTX compared to those who took placebo experienced any type of side effect (common or rare) (ATB 30, 95% CI 13% to 47%). No statistically significant differences were observed in the total number of serious adverse events between the MTX group and the placebo group at 27 to 52 weeks. Three people out of 100 who took MTX alone experienced rare but serious side effects compared to 2 people out of 100 who took a placebo (3% versus 2%, respectively).
Different forms of arthritis have different root causes. Rheumatoid arthritis and psoriatic arthritis are examples of “inflammatory arthritis,” also described as autoimmune arthritis. This occurs when the immune system generates internal inflammation to get rid of perceived threats (like an infection or allergy) and mistakenly causes joint erosion and sometimes organ damage. These forms of arthritis are especially important to treat as early on as possible, since tissue damage can be hard to reverse once it sets in. Inflammatory arthritis is believed to be highly tied to gut health, which means a healthy diet is key for recovery.
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