Warfarin interactions with steroids

A recent study suggests that the
response to warfarin is influenced by
polymorphisms in cytochrome P-450
2C9. 17 Patients with these polymorphisms
have impaired S-warfarin
metabolism and increased response.
Future investigations need to take
into account patients' CYP 2C9 genotype.
This is because a markedly increased
response to warfarin early in
the course of therapy may be attributable
to a polymorphism rather than--
or in addition to--a disease state or
drug interaction.

The terminal half-life of Warfarin after a single dose is approximately 1 week; however, the effective half-life ranges from 20 to 60 hours, with a mean of about 40 hours. The clearance of R-Warfarin is generally half that of S-Warfarin, thus as the volumes of distribution are similar, the half-life of R-Warfarin is longer than that of S-Warfarin. The half-life of R-Warfarin ranges from 37 to 89 hours, while that of S-Warfarin ranges from 21 to 43 hours. Studies with radiolabeled drug have demonstrated that up to 92% of the orally administered dose is recovered in urine. Very little Warfarin is excreted unchanged in urine. Urinary excretion is in the form of metabolites.

Signs of overdose include bleeding gums , bruising, nosebleeds, heavy menstrual bleeding, and prolonged bleeding from cuts . Quick Guide Heart Disease: Symptoms, Signs, and Causes From Tips to Better Manage Your Migraine Start Now What is the dosage for warfarin?

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

Warfarin interactions with steroids

warfarin interactions with steroids

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

Media:

warfarin interactions with steroidswarfarin interactions with steroidswarfarin interactions with steroidswarfarin interactions with steroidswarfarin interactions with steroids

http://buy-steroids.org